The POLR1A antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to POLR1A. This antibody recognizes Homo Sapiens, and Human antigen. The POLR1A antibody has been validated for the following applications: EIA, Immunoassay, ELISA, and Western Blot.
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition(By similarity)